Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism
نویسندگان
چکیده
منابع مشابه
Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism.
The transcriptional regulation of several dozen genes in response to low oxygen tension is mediated by hypoxia-inducible factor 1 (HIF-1), a heterodimeric protein composed of two subunits, HIF-1alpha and HIF-1beta. In the HIF-1alpha-deficient human leukemic cell line, Z-33, exposed to mild (8% O(2)) or severe (1% O(2)) hypoxia, we found significant upregulation of two related heterogenous nucle...
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15 صفحه اولThe Regulation of Trypanosome Gene Expression by RNA-Binding Proteins
The genome organization of trypanosomes, leishmanias, and related kinetoplastid organisms is highly unusual: Each RNA polymerase II promoter precedes multiple open reading frames, and the primary transcript is cut into individual mRNAs by 59 trans splicing and 39 polyadenylation [1]. Dedicated control of transcription at the level of individual mRNAs is therefore not possible. Nevertheless, mRN...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2004
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.01026